A recent review by the researchers in Prof. Tewfik Soulimane's group, Department of Chemical and Environmental Science has been featured on the cover of FEBS Letters.
This review entitled “Cation Diffusion Facilitator Family: Structure and Function” by Kolaj-Robin et al. summarized the group's current research and a mechanistic understanding into this membrane protein family. The Cation Diffusion Facilitators (CDFs) are an ubiquitous family of secondary transporters thought to play a key role in metal resistance and tolerance in all three kingdoms of life. CDFs in humans are crucial for metal sequestration and an imbalance in such processes is linked to Alzheimer’s disease and prostate cancer. The group was also the first to identify a functional sub-group of CDFs lacking a canonical region (C-terminal cytoplasmic domain) that was previously thought to be requisite for their function. This identification has the potential to lead to structure-based drug design to combat microbial pathogens.