arrow
Search icon

Dr Adam Orłowski Profile

Adam Orłowski

 

Position: Postdoctoral Researcher

Group: Atomic-scale materials design (Assembled)

Contact details:

Department of Physics and Energy

University of Limerick, Limerick

Ireland

Email: adam.orlowski@ul.ie

 

EDUCATION

  • PhD with distinction in computational biophysics, Tampere University of Technology, Finland (2010 – 2014). Thesis title: “Membrane-Associated Proteins Do Care about Lipids – Perspective Based on Atomistic Molecular Dynamics Simulations
  • MSc in biophysics, Faculty of Biochemistry, Biotechnology and Biophysics, Jagiellonian University, Poland (2005-2010). Thesis title: “Influence of the biological membrane on the transport of neurotransmitters”

 

WORK AND RESEARCH EXPERIENCE

  • Postdoctoral Researcher, University of Limerick, Ireland (2015-)
  • Analyst at Forensic Technology & Discovery Services at EY (Ernst&Young), Warsaw, Poland (2015)
  • Researcher at the Department of Physics, Tampere University of Technology, Finland (2010-2014)
  • Research assistant and visiting scientist at the Department of Physics, Tampere University of Technology, Finland. Industrial-academic project with the company Stora-Enso (2009-2010)
  • Scholarship granted by the European Union exchange program “Erasmus” at the University of Helsinki, Finland. Faculty of Pharmacy (2008)

 

Short description (Bio):

Adam Orłowski got his Master’s degree in biophysics at the Jagiellonian University in Krakow. During his studies he spent some time working at the Centre for Drug Research at the University of Helsinki and Tampere University of Technology in Finland. He then started PhD studies in the group of Prof. Ilpo Vattulainen at the Tampere University of Technology. His PhD thesis research focused mainly on studies of lipid-protein interactions using biomolecular simulations, but he was also involved in projects from other fields, ranging from neurochemistry to nanotechnology to protein-sugar interactions. After his PhD, Adam took a short break from research and worked for a while as an analyst in the Forensic Technology division of one of the “big four” consulting companies. He joined the Atomic-scale materials design (Assembled) group of Dr. Damien Thompson in late 2015 and is currently studying protein-sugar interactions in the EU FP7 CellulosomePlus project and will continue these studies in an Enterprise Ireland funded project starting in early 2016.

Publication list:

  1. T. Róg, A. Orłowski, A. Llorente, T. Skotland, T. Sylvänne, D. Kauhanen, K. Ekroos, K. Sandvig, I. Vattulainen. Interdigitation of Long-Chain Sphingomyelin Induces Coupling of Membrane Leaflets in a Cholesterol Dependent Manner. BBA – Biomembranes. 1858(2):281-8 (2016)
  2. T. Róg, A. Orłowski, A. Llorente, T. Skotland, T. Sylvänne, D. Kauhanen, K. Ekroos, K. Sandvig, I. Vattulainen. (2016). Data including GROMACS input files for atomistic molecular dynamics simulations of mixed, asymmetric bilayers including molecular topologies, equilibrated structures, and force field for lipids compatible with OPLS-AA parameters. Data in Brief. 7, 1171–1174.
  3. K. Kaszuba, M. Grzybek, A. Orłowski, R. Danne, T. Róg, K. Simons, Ü. Coskun, I. Vattulainen.  N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranesPNAS.  112(14):4334–4339 (2015)
  4. A. Orłowski, S. Kukkurainen, A. Pöyry, S. Rissanen, I. Vattulainen, V. Hytönen, T. Róg. PIP2 and Talin Join Forces to Activate Integrin. Journal of Physical Chemistry B. 119(38):12381-9 (2015) 

  5. A. Orłowski, T. Róg, S. Paavilainen, M. Manna, I. Heiskanen, K. Backfolk, J. Timonen, I. Vattulainen. How endoglucanase enzymes act on cellulose nanofibrils: Role of amorphous regions revealed by atomistic simulations. Cellulose 1-15 (2015) 

  6. R. Ghosh, M.K.F. Campos, J. de, Huang, S.K. Huh, A. Orlowski, Y. Yang, A. Tripathi, A. Nile, H.-C. Lee, M. Dynowski, H. Schäfer, T. Róg, M.G. Lete, H. Ahyayauch, A. Alonso, I. Vattulainen, T.I. Igumenova, G. Schaaf, V.A. Bankaitis. Sec14-Nodulin Proteins And The Patterning of Phosphoinositide Landmarks For Developmental Control of Membrane Morphogenesis. Mol. Biol. Cell. :mbc.E14–10–1475 (2015) 

  7. A. Llorente, T. Skotland, T. Sylvänne, T. Rog, D. Kauhanen, A. Orłowski, I. Vattulainen, K. Ekroos, K. Sandvig. Molecular Lipidomics of Exosomes Released by PC-3 Prostate Cancer Cells. BBA Molecular and Cell Biology of Lipids 1831, 1302–1309 (2013)
  8. A. Orłowski, M. Grzybek, A. Bunker, M. Pasenkiewicz‐Gierula, I. Vattulainen, P. T Männistö, T. Róg. Strong preferences of dopamine and l-dopa towards lipid head group: importance of lipid composition and implication for neurotransmitter metabolism. Journal of Neurochemistry 122, 681–690 (2012)
  9. L. Monticelli, J. Barnoud, A. Orłowski, I. Vattulainen. Lipid-mediated interaction of C70 fullerene with the Kv1.2 potassium channel. Phys. Chem. Chem. Phys. 14, 12526–12533 (2012).
  10. H. J. Kaiser, A. Orłowski, T. Róg, T. K. M. Nyholm, W. Chai, T. Feizi, D. Lingwood, I. Vattulainen, K. Simons. Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching. PNAS 108, 16628 (2011)
  11. M. Stepniewski, M. Pasenkiewicz-Gierula, T. Rog, R. Danne, A. Orłowski, M. Karttunen, A. Urtti, M. Yliperttula, E. Vuorimaa, A. Bunker. Study of PEGylated Lipid Layers as a Model for PEGylated Liposome Surfaces: Molecular Dynamics Simulation and Langmuir Monolayer Studies. Langmuir 27, 7788–7798 (2011)
  12. A. Orłowski, J-F. St. Pierre, A. Magarkar, A. Bunker, M. Karttunen, I. Vattulainen, M. Pasenkiewicz-Gierula, T. Róg. Properties of the Membrane Binding Component of Catechol-O-Methyltransferase Revealed by Atomistic Molecular Dynamics Simulations. Journal of Physical Chemistry B 115, 13541–13550 (2011)
  13. A. Llorente, T. Skotland, T. Sylvänne, T. Rog, D. Kauhanen, A. Orłowski, I. Vattulainen, K. Ekroos, K. Sandvig. Molecular Lipidomics of Exosomes Released by PC-3 Prostate Cancer Cells. BBA Molecular and Cell Biology of Lipids 1831, 1302–1309 (2013)