Peptide Drug Delivery PhD Project
Department of Chemical Sciences, University of Limerick
Start date open
Supervisor: Dr Sarah Hudson
Figure 1. Activity of different salts forms of an antimicrobial agent against Staphylococcus Aureus bacteria.
This PhD project will involve the development of novel delivery matrices for antimicrobial peptides for pharmaceutical applications. The project will involve chemical synthesis of polymeric and ceramic gels and particles that can be used as peptide delivery matrices for oral, inhalable, injectable or topical administration routes. The physicochemical properties, solubility, stability, bioactivity and toxicity, of the peptides will be characterised before, during and after loading into the delivery matrix. Experimental and analytical skills in materials chemistry, chromatography, mass spectroscopy and mammalian and microbial cell culturing will be acquired during this PhD. Industry collaboration will be encouraged and a placement to industry will form part of the PhD project. The PhD project will sit within the Synthesis and Solid State Pharmaceutical Centre and the training and development opportunities of the centre will be available to the successful candidate.
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